Submitted: 05 Jul 2019
Accepted: 06 Oct 2018
First published online: 07 Nov 2018
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J Renal Inj Prev. 2019;8(2):98-105.
doi: 10.15171/jrip.2019.19
  Abstract View: 134
  PDF Download: 389

Original

Comparison the effect of high flux and low flux dialyzer on quality of life in hemodialysis patients; a clinical trial

Khodayar Oshvandi 1, Mehri Safari 2, Mahmood Gholyaf 3, Abbas Moghim-Beygi 4, Farshid Shamsaei 5 * , Mohammadreza Tamadon 6, Neda Alimohammadi 7

1 Chronic Disease (Home Care) Research Center, Nursing and Midwifery School, Hamadan University of Medical Sciences, Hamadan, Iran
2 Nursing and Midwifery School, Hamadan University of Medical Sciences, Hamadan, Iran
3 Department of Nephrology, Shaheed Beheshti Hospital, Urology and Nephrology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
4 Department of Biostatistics and Epidemiology, Modeling of Non communicable Diseases Research Center, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran
5 Mother and Child Care Research Center, Nursing and Midwifery School, Hamadan University of Medical Sciences, Hamadan, Iran
6 Department of Nephrology, Semnan University of Medical Sciences, Semnan, Iran
7 Department of Medical-Surgical Nursing, Instructor, School of Nursing and Midwifery, Hamadan University of Medical Sciences, Hamadan, Iran
*Corresponding author: Farshid Shamsaei, Email: shamsaei68@yahoo.com, Email: shamsaei@umsha.ac.ir

Article

Introduction: End-stage renal disease (ESRD) is a worldwide public health problem. ESRD reduces health-related quality of life. Quality of life is an important determinant in the mortality and morbidity of hemodialysis patients. However, several studies have suggested that high flux dialyzers increase dialysis adequacy and reduce mortality and morbidity in these patients.

Objectives: This study aimed to investigate the effects of high flux and low flux dialyzers on the quality of life in hemodialysis patients.

Patients and Methods: In this clinical trial, 93 patients who met the inclusion criteria were randomly assigned to two groups of high flux and low flux dialyzers. Before intervention, both groups filled demographic and quality of life questionnaires. They were undergone dialysis with two dialyzers (one group by high flux and another by low flux) three times a week for 6 weeks. Then quality of life questionnaire was filled by both groups once again.

Results: The overall quality of life score was not significantly different in both groups before intervention (P=0.121). After intervention, however, high flux group attained a significantly higher mean score (54 ± 10.4) than low flux group (43.89 ± 11.64) (P<0.001).

Conclusion: According to the results of this study, the use of high flux dialyzers can be a useful method to increase the quality of life in hemodialysis patients.

Implication for health policy/practice/research/medical education:

In a study on 93 hemodialysis patients (49 patients with low flux and 44 patients with high flux dialyzers), a significant difference of quality of life between the two groups was detected. High flux dialyzers can be a useful method to increase the quality of life in hemodialysis patients.

Please cite this paper as: Oshvandi K, Safari M, Gholyaf M, Moghim-Beygi A, Shamsaei F, Tamadon MR, et al. Comparison the effect of high flux and low flux dialyzer on quality of life in hemodialysis patients; a clinical trial. J Renal Inj Prev. 2019;8(2):98- 105. DOI: 10.15171/jrip.2019.19.

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