Submitted: 03 Apr 2019
Accepted: 20 May 2019
First published online: 15 Jun 2019
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J Renal Inj Prev. 2019;8(3):235-239.
doi: 10.15171/jrip.2019.44
  Abstract View: 145
  PDF Download: 82

Original

In vitro effect of hydroalcoholic extract of Peganum harmala on human ureteric contractions

Majid Shirani 1 ORCiD, Zahra Lorigooini 2 ORCiD, Arsham Pouriamofrad 3 ORCiD, Zahra Keivani Hafshejani 3 * ORCiD

1 Department of Urology, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
3 Deputy of Research and Technology, Shahrekord University of Medical Sciences, Shahrekord, Iran
*Corresponding author: Zahra Keivani Hafshejani, Email: Email: keivaniz@yahoo.com

Article

Introduction: Ureteral obstruction by stones is one of the most common urological problems.

Objectives: This study aimed to investigate the in vitro effects of hydroalcoholic extract of Peganum harmala L. on the contraction of the human ureter.

Materials and Methods: In this study, 28 samples of human ureter tissue were studied. Six tissue samples were examined for the evaluation of P. harmala extract at concentrations of 1, 2, and 4 mg/mL. Moreover, five tissue samples were examined for checking NaCl solution since, six pieces of tissue for the examination of prazosin 10-8M solution.

Results: There was a significant difference between the second contraction of P. harmala group with concentration of 4 mg/mL and NaCl group (P<0.001). Additionally, a significant difference between the prazosin and P. harmala groups with a concentration of 4 mg/mL (P=0.048) was observed. There is a marginal difference between the secondary contractions in two groups. A significant decrease in secondary contraction (15 minutes after adding the solution) was observed between the prazosin group and the P. harmala group at a concentration of 1 mg/mL (P<0.001). Moreover, the secondary contraction of the prazosin group showed a significant decrease compared with the NaCl group (P<0.001).

Conclusion: Administration of P. harmala extract can be useful in reducing urinary human ureteric contractions while the best effect was achieved at 4 mg/mL of P. harmala extract.

Implication for health policy/practice/research/medical education:

Administration of Peganum harmala extract can be useful in reducing urinary ureteric contractions as a supplementary drug.

Please cite this paper as: Shirani M, Lorigooini Z, Pouriamofrad A, Keivani Hafshejani Z. In vitro effect of hydroalcoholic extract of Peganum harmala on human ureteric contractions. J Renal Inj Prev. 2019;8(3):235-239. DOI: 10.15171/jrip.2019.44.

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