Mahmoud Rafieian-Kopaie
1*1 Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
*Corresponding Author: *Corresponding author: Prof. Mahmoud Rafieian-Kopaei, Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran., Email:
rafieian@yahoo.com
Abstract
Implication for health policy/practice/research/medical education:Metformin protects against tubular injury by modulation of oxidative stress on the tubules and restoring the biochemical alterations. While in diabetes, glycosuria causes tubular cell injury. Furthermore metformin is able to protect podocytes in diabetic nephropathy. These findings may suggest the clinical use of metformin in the prevention of diabetic nephropathy.