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ePublished: 01 Sep 2015
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J Renal Inj Prev. 2015;4(3): 68-72.
doi: 10.12861/jrip.2015.14
PMID: 26468477
PMCID: PMC4594216
  Abstract View: 2659
  PDF Download: 1221

Original Article

The effect of omega-3 on serum lipid profile in hemodialysis patients

Hamid Reza Omrani 1, Yahya Pasdar 2*, Daryosh Raisi 3, Farid Najafi 4, Ardeshir Esfandiari 5

1 Department of Internal Medicine, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
2 Department of Nutrition, School of Public Health, Kermanshah University of Medical Sciences, Kermanshah, Iran
3 Department of Internal Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
4 Research Center of Environmental Determinant of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran
5 Department of Internal Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
*Corresponding Author: *Corresponding author: Yahya Pasdar, , Email: yahya.pasdar@kums.ac.ir

Abstract

Introduction: One of the major complications in hemodialysis patients is cardiovascular disease. Lipid abnormality is an important factor in the development of cardiovascular disease.

Objectives: To investigate the effect of omega-3 supplementation on serum lipid profile in hemodialysis patients.

Patients and Methods: This randomized clinical trial study included 2 groups of patients: those who received omega-3 supplementation (experimental group; 30 cases) and those who received placebo (control group; 30 cases). They received these for 10 weeks and serum lipid profile (triglyceride, high-density lipoprotein [HDL-C], low-density lipoprotein [LDL-C], and total cholesterol) was assessed 2 times, first before initiating supplementation and then at the end of 10-week study period.

Results: Mean (±SD) serum total cholesterol levels at the beginning was 163 (±47) mg/dL in experimental group and 143 (±25) mg/dL in control group (P> 0.05). These values decreased to 124 mg/dL and 132 mg/dL in control and experimental groups (P< 0.05). There was no significant difference of HDL-C, LDL-C, or triglyceride levels between experimental and control groups after 10 weeks of treatment.

Conclusion: Omega-3 supplementation in hemodialysis patients only showed significant decrease of serum total cholesterol level, but not other lipids.


Implication for health policy/practice/research/medical education:

Since there is controversy about omega-3 supplementation on lipid profile in patients with hemodialysis patients, we conducted a study to determine the role of omega-3 in such patients. Our results showed that in short-term follow-up omega-3supplementation, the only finding was significant decrease in serum total cholesterol.

Please cite this paper as: Omrani HR, Pasdar Y, Raisi D, Najafi F, Esfandiari A. The effect of omega-3 on serum lipid profile in hemodialysis patients. J Renal Inj Prev. 2015; 4(3): 68-72. DOI: 10.12861/jrip.2015.14

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