Faezeh Kiani
1 
, Fatemeh Sayehmiri
2 , Ali Hasanpour Dehkordi
3 , Morteza Motedayen
4* 1 Research Center for Prevention of Psychosocial Impairment, Ilam University of Medical Sciences, Ilam, Iran
2 Student Research Committee, Proteomics Research Center, Shahid-Beheshti University of Medical Sciences, Tehran, Iran
3 Social Determinants of Health Research Center, School of allied medical Sciences, Shahrekord University of Medical Sciences, Shahrekord, Iran
4 Cardiology Department, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
Abstract
Type 2 diabetes mellitus (T2DM) is a multi-factorial disease in which influenced by several
genetic and environmental factors. Insulin receptor substrate 2 (IRS 2) is the main mediator
of insulin in the liver which controls insulin sensitivity. Gly1057Asp polymorphism is one
of the candidates to increase risk of T2DM. The present study is an attempt to study the
relationship of Gly1057Asp polymorphism of IRS-2 and T2DM by a meta-analysis. A systemic
search was conducted in English and Persian databases such as Scopus, PubMed, Google
Scholar, SID, and other academic databases for studies that have investigated the relationship
of Gly1057Asp polymorphism of IRS-2 and T2DM. This association was determined using
odds ratios (ORs) with a confidence interval of 95% (CIs). Heterogeneity of the studies was
examined by I2
index. Funnel plots and Egger tests were used to determine bias or publication
bias. The collected data was analyzed in STATA through meta-analysis. Nine articles were
selected as eligible for further analysis, which represented 3,196 patients with T2DM and 3409
controls subjects without T2DM. The present meta-analysis showed a significant relationship
between GA genotype of Gly1057Asp polymorphism and T2DM (OR=0.88; 95% confidence
interval, 0.79-0.98), whereas no significant relationship between GG and AA genotype with
T2DM was seen; OR for GG and AA genotypes were 1.10 (95% CI, 0.99 -1.22) and 1.13 (95%
CI, 0.95- 1.33), respectively. The results of our study show that genotype GA of Gly1057Asp
polymorphism of IRS-2 gene plays a protective role and may decrease the risk of T2DM,
whereas GG and AA genotypes are considered as a risk factor and related to development of
T2DM to some extents.
Implication for health policy/practice/research/medical education:
The present meta-analysis showed a significant relationship between GA genotype of Gly1057Asp polymorphism and type
2 diabetes mellitus (OR=0.88; 95% confidence interval, 0.79-0.98), whereas no significant relationship between GG and AA
genotype with type 2 diabetes mellitus was seen; OR for GG and AA genotypes were 1.10 (95% CI, 0.99 -1.22) and 1.13 (95% CI,
0.95-1.33), respectively.
Please cite this paper as: Kiani F, Sayehmiri F, Hasanpour Dehkordi A, Motedayen M. Surveying the relationship between
Gly1057Asp polymorphism of IRS-2 gene and susceptibility to type 2 diabetes; a systematic review and meta-analysis study. J
Renal Inj Prev. 2019;8(4):263-270. DOI: 10.15171/jrip.2019.50.