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Submitted: 10 Apr 2021
Accepted: 25 Aug 2021
ePublished: 11 Dec 2021
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J Renal Inj Prev. 2022;11(4): e32000.
doi: 10.34172/jrip.2022.32000
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  PDF Download: 276

Original

The role of remote ischemic preconditioning in preventing contrast-induced nephropathy following invasive coronary angiography; a randomized controlled trial

Mohammadmehdi Peighanbari 1 ORCID logo, Hoda Raffieijelodar 2 ORCID logo, Zahra Shafii 2* ORCID logo

1 Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
2 Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
*Corresponding Author: Corresponding author: Zahra Shafii, Email: , Email: shafii_zahra@yahoo.com

Abstract

Introduction: Remote ischemic preconditioning (RIPC) is now proposed as an effective approach for preventing contrast-induced nephropathy (CIN); however, the results on its efficacy have already remained uncertain.

Objectives: We aimed to assess the beneficial effects of RIPC in preventing CIN in patients undergoing coronary angiography (CA) followed by angioplasty.

Patients and Methods: One hundred patients candidate for elective CA and coronary angioplasty, moderate to high risk for CIN were randomized into two groups including the group which planned for RIPC, and the control group. The overall prevalence rate of CIN was assessed and compared across the two groups.

Results: The two groups were matched for demographics, cardiovascular risk profiles and laboratory parameters. The prevalence of CIN in RIPC group was 14.0% and in the control group was 26.0% indicating no statistical difference between the two groups (P = 0.105). Requiring dialysis was also planned for 0.0% and 2.0% respectively with no difference (P = 0.500).

Conclusion: RIPC may not prevent CIN in patients who are candidate for invasive CA.

Trial Registration: The study was approved in the Iranian Registry of Clinical Trials (identifier: IRCT20171230038144N1; https://www.irct.ir/trial/28715, ethical code: IR.IUMS. FMD.REC 1396.9311171014).


Implication for health policy/practice/research/medical education:

In the current RCT on 100 patients candidate for elective coronary angiography and angioplasty, we found RIPC may not prevent CIN in patients who are moderate to high risk for contrast induced nephropathy after invasive coronary angiography.

Please cite this paper as: Peighanbari M, Raffieijelodar H, Shafii Z. The role of remote ischemic preconditioning in preventing contrast-induced nephropathy following invasive coronary angiography; a randomized controlled trial. J Renal Inj Prev. 2022; 11(4): e32000. doi: 10.34172/jrip.2022.32000.

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