Zahra Bazargani
* 
1 Clinical Research Development Unit, Department of Pediatric, Valiasr Hospital, Fasa University of Medical Sciences, Fasa, Iran
Abstract
The management of kidney disease is witnessing a paradigm shift, driven by the emergence of innovative renoprotective agents and a deeper understanding of disease mechanisms. This review highlights the latest pharmacological advancements and therapeutic strategies aimed at preserving renal function and improving outcomes for patients with kidney disease. Key developments include the exploration of cell therapy and regenerative medicine, particularly the use of renal progenitor cells to repair damaged kidney tissue, and the groundbreaking application of kidney organoids, which offer new insights into disease pathology and personalized treatment approaches. Additionally, the shift toward combination therapies, such as the concurrent use of SGLT2 (sodium-glucose cotransporter 2) inhibitors with other kidney-protective agents, demonstrates significant promise in addressing the multifactorial nature of kidney disease progression. Beyond pharmacological interventions, the integration of lifestyle modifications, including dietary adjustments, physical activity, and risk factor management remains fundamental to both prevention and treatment. As we commemorate world kidney day, this review also emphasizes the importance of a multidisciplinary approach, combining cutting-edge pharmacological innovations with holistic lifestyle strategies to combat the global burden of kidney disease and improve patient outcomes.
Implication for health policy/practice/research/medical education:
The global burden of kidney disease represents a critical public health challenge that demands immediate attention and coordinated action. The combination of increasing prevalence, economic burden, and healthcare disparities creates a complex challenge that requires innovative solutions and global collaboration. As we move forward, addressing this crisis will require a multi-layered approach that combines access to care, development of novel therapeutics, and attention to environmental and also social determinants of health. Success in reducing the global burden of kidney disease will depend on sustained commitment from healthcare providers, policymakers, and the international community to implement comprehensive strategies that address both prevention and treatment while ensuring equitable access to care for all populations.
Please cite this paper as: Bazargani Z. Emerging trends in renoprotective agents; a pharmacological perspective for world kidney day 2025. J Renal Inj Prev. 2025; 14(2): e38444. doi: 10.34172/jrip.2025.38444.