Tahereh Zabihi
1 
, Roya Biglarifar
2 , Samaneh Saghafian Larijani
3* 1 Department of Internal Medicine, Firoozabadi Clinical Research Development Unit, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
2 Department of Obstetrics and Gynecology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
3 Department of Obstetrics and Gynecology, Firoozabadi Clinical Research Development Unit, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Abstract
Preeclampsia can have long-term effects on kidney function in women with chronic kidney disease (CKD). Women with a history of preeclampsia have an increased risk of CKD and end-stage renal disease (ESRD) later in life. Regular check-ups are needed for preeclamptic women, especially those with persistent hypertension or proteinuria. Therefore, prediction models incorporating renal function and pregnancy outcomes in the first trimester can help assess pregnancy risk in CKD patients. Risk stratification models consider disease activity, major organ involvement, maternal risk factors and comorbidities, previous pregnancy complications, teratogenic drugs, and laboratory tests.
Implication for health policy/practice/research/medical education:
Preeclampsia significantly impacts long-term kidney health, increasing a woman’s risk for various renal complications later in life. This condition illustrated by new-onset hypertension and proteinuria after 20 weeks of gestation, which leads to both short-term kidney injury and heightened susceptibility to chronic kidney disease (CKD) and even end-stage renal disease (ESRD).
Please cite this paper as: Zabihi T, Biglarifar R, Saghafian Larijani S. Risk prediction for preeclampsia in pregnant women with chronic kidney disease. J Renal Inj Prev. 2025; x(x): e38679. doi: 10.34172/jrip.2025.38679.