Abstract
Introduction: Acute kidney injury (AKI) is a frequent problem in pediatric intensive care
units, while it is associated with significant mortality.
Objectives: The aim of this study was to determine the prevalence and prognosis of AKI
based on pRIFLE (pediatric risk, injury, failure, loss, end-stage renal disease) criteria among
children admitted to a pediatric intensive care unit
Patients and Methods: This research included 323 children from 1 month to 14 years old age,
admitted to the pediatric intensive care unit. The pRIFLE was determined in patients along
with urinary output and creatinine level. The pediatric risk of mortality (PRISM) score was
also assessed.
Results: Mean PRISM III score was 34.66 ± 15.97 and 17.72 ± 6.06 respectively in children
with and without AKI (P=0.001). It was found that variables of encephalopathy, PRISMIII
score and gender were the only variables affecting the incidence of AKI.
Conclusion: While pRIFLE criteria are appropriate and efficient criteria for early diagnosis of
AKI, their role alone as prognostic factors of mortality require further studies.