Nickan Research Institute Journal of Renal Injury Prevention 2345-2781 2 3 2013 09 10 Metformin and renal injury protection 91 92 10.12861/jrip.2013.29 EN Mahmoud Rafieian-Kopaie EDITORIAL 10.12861/jrip.2013.29 Implication for health policy/practice/research/medical education:Metformin protects against tubular injury by modulation of oxidative stress on the tubules and restoring the biochemical alterations. While in diabetes, glycosuria causes tubular cell injury. Furthermore metformin is able to protect podocytes in diabetic nephropathy. These findings may suggest the clinical use of metformin in the prevention of diabetic nephropathy.