Nickan Research Institute Journal of Renal Injury Prevention 2345-2781 1 1 2012 01 01 Serum uric acid and diabetic nephropathy 37 38 10.12861/jrip.2012.13 EN Ali Momeni Journal Article 10.12861/jrip.2012.13 Implication for health policy/practice/research/medical education:Diabetic nephropathy is the most common cause of end-stage renal disease worldwide. Recently, some prospective randomized controlled trials suggested that lowering of uric acid with allopurinol could decrease the severity of proteinuria and probably slow the progression of renal failure in diabetic patients. Mechanism of beneficial effect of xanthine oxidase inhibitor may related to preventing uric acid-induced renal inflammation.