Nickan Research Institute Journal of Renal Injury Prevention 2345-2781 2 4 2013 12 01 Light chain deposition disease; there are reasons for confusion 127 128 10.12861/jrip.2013.41 EN Mohammad-Reza Ardalan LETTER 10.12861/jrip.2013.41 Implication for health policy/practice/research/medical education:Congo red negative nodular deposition of an amorphous, eosinophilic material is the most common pathologic finding in light chain deposition disease in light microscopy. The nodules are a mixture of light chain and mesangial protein and the picture is reminiscent of diabetic nephropathy. Immunoflurescent microscopy usually demonstrates the presence of monotypic kappa light chain. It seems that serum creatinine level greater than 4 mg/dl is a poor prognosis sign for future progress to end stage renal disease in this disease. Therefore, early diagnosis is important.