Nickan Research Institute Journal of Renal Injury Prevention 2345-2781 3 1 2014 03 01 Unanswered questions in childhood idiopathic nephrotic syndrome 1 2 10.12861/jrip.2014.01 EN Ali Lanewala Muhammed Mubarak EDITORIAL 10.12861/jrip.2014.01 Implication for health policy/practice/research/medical education IgM nephropathy (IgMN) is a controversial clinicoimmunopathologic entity in the arena of primary glomerulopathies. Recently, many clinicopathological studies have been published, but there is severe lack of information on etiopathogenesis of the condition. A recent study has found that naturally occurring IgM antibody is pathogenic and plays a role in causing damage in animal models and focal segmental glomerulosclerosis (FSGS). This study provides an important stimulus for basic research focused on elucidating the pathophysiology of IgMN.