Nickan Research Institute Journal of Renal Injury Prevention 2345-2781 3 1 2014 03 01 The definition and detection of acute kidney injury 21 25 10.12861/jrip.2014.08 EN John W Pickering Zoltán H Endre Journal Article 10.12861/jrip.2014.08 The first consensus definition of Acute Kidney Injury (AKI) was published a decade ago. In this mini narrative review we look at the history of the changes in the definition of AKI and consider how it may change again in the near future. The epidemiology of small changes in creatinine and the difficulties with determining baseline creatinine have driven the changes. Recent evidence on urinary output and the application of structural injury biomarkers are likely to change the definition once more.