Nickan Research Institute Journal of Renal Injury Prevention 2345-2781 6 3 2017 09 01 Urinary level of interleukin-1alpha and interleukin-6 in patients underwent extracorporeal shock wave lithotripsy 231 235 10.15171/jrip.2017.43 EN Mohsen Rajabnia Chenari Faramarz Fazeli Mehdi Jahantigh Javid Dehghan Amin Zarghami Mohammad Bahadoram Ali Ghorbani Sajedeh Mirshahvalad Journal Article 10.15171/jrip.2017.43 Introduction: Extracorporeal shock wave lithotripsy (ESWL) was established as a dramatic procedure in the treatment of urinary stones. According to the growing utilization of ESWL as a major method of urinary stone, management and the reports have been reported based on renal tissue damage. Objectives: We decided to examine the severity of ESWL-induced renal tissue damage and its related factors by monitoring the urinary levels of cytokines. Patients and Methods: In this study, the urinary samples of 32 patients with urolithiasis were taken before, 24 hours and 14 days after ESWL and interleukin-1ɑ (IL-1a) and interleukin-6 (IL-6) levels were measured by enzyme-linked immunosorbent assay (ELISA) method. Results: Our findings indicated that there was a significant difference between the urinary levels of both IL-1ɑ and IL-6 in 14 days before and after ESWL. Conclusion: According to our results, ESWL leads to an inflammatory process in the urinary tract and the inflammation have continuously increased up to 14 days after procedure.