Nickan Research Institute Journal of Renal Injury Prevention 2345-2781 6 4 2017 12 01 Fenugreek (Trigonella foenum-graecum) induced interstitial nephritis 286 288 10.15171/jrip.2017.54 EN Sepideh Zununi-Vahed Mohammadreza Ardalan Fariba Mahmoodpoor Kasra Ardalan Ramin Tolouian Journal Article 10.15171/jrip.2017.54 Herbal medicine has grabbed the public interest and there is a general belief of their safety and life compatibility. There are growing proportion of reported side effects of herbal medicine in past years. We reported a 62-year-old woman who developed acute interstitial nephritis (AIN) accompanied by autoimmune hemolytic anemia (AIHA), three weeks after daily ingestion of heat extract of fenugreek. The patient’s renal, hematologic and liver panels were improved after steroid pulse therapy and fenugreek discontinuation. Fenugreek contains high amount of flavonoid which might be a main culprit for AIN and AIHA.