Nickan Research Institute Journal of Renal Injury Prevention 2345-2781 9 4 2020 12 01 Acute interstitial nephritis with immunotherapy; a growing entity? e35 e35 10.34172/jrip.2020.35 EN John David Chetwood https://orcid.org/0000-0002-8947-9817 Lin Lin Myat https://orcid.org/0000-0001-8532-2620 Helen Lammi Mani Panat https://orcid.org/0000-0001-6944-1486 James Hughes https://orcid.org/0000-0001-5446-1927 Journal Article 10.34172/jrip.2020.35 2020 03 12 2020 05 01 We report a case of acute kidney injury (AKI) secondary to immune-mediated acute interstitial nephritis (AIN), with supporting diagnostic results and a successful response to treatment. This entity is gaining increasing recognition with the burgeoning use of immunotherapy agents in oncology. The timeline for the development of AIN from the initiation of immunotherapy varies, and may range in severity from asymptomatic to severe, organ-threatening and with life threatening consequences. Renal biopsy should be performed to confirm the diagnosis due to the potential impact of discontinuation of immunotherapy on cancer survival. Re-challenge with immunotherapy is reasonable once renal function recovers.