Nickan Research Institute Journal of Renal Injury Prevention 2345-2781 12 1 2023 03 01 The relationship between fluid balance and the incidence of post-operative acute kidney injury during and 24 hours after coronary artery bypass graft surgery e22753 e22753 10.34172/jrip.2022.22753 EN Seyed Mostafa Alavi https://orcid.org/0000-0001-9466-6118 Elham Shahidi Delshad Houshang Sanadgol Mohsen Ziyaeifard https://orcid.org/0000-0002-5631-4813 Seyedehsara Bayesh https://orcid.org/0000-0002-5671-8340 Mohammadreza Foroutan Mostafa Saberian Journal Article 10.34172/jrip.2022.22753 2019 04 14 2020 06 06 Introduction: Around 30% of patients undergoing cardiac surgery experience acute kidney injury (AKI). Objectives: The purpose of this study was to determine the relationship between fluid overload and serum creatinine changes in patients undergoing coronary artery bypass grafting (CABG) surgery. Patients and Methods: a total of 130 patients undergoing CABG surgery were entered into the study using cardiopulmonary bypass (CPB). The fluid balance for each patient was calculated for 24 hours after surgery. Each patient was classified into one of these three groups; 1) Patients with a fluid balance of less than 2000 mL; 2) Patients with fluid balance of 2000 to 3000 mL; 3) Patients with a fluid balance of more than 3000 mL. Serum creatinine changes and renal failure were studied in these three groups. Results: After multivariate analysis of the factors affecting the incidence of AKI, we found a significant relationship between the administration of inotrope and AKI incidence (P=0.001, 75.1875 to 847.5, 95% CI, 664/89, OR). However, there is no significant relationship between the incidence of AKI and the high fluid balance. Conclusion: There are many interactions between renal function and fluid balance during a cardiovascular-pump. According to the results of our study, the high fluid balance in patients has a minor effect on serum creatinine.