Nickan Research Institute Journal of Renal Injury Prevention 2345-2781 11 1 2022 03 01 Methicillin-resistant Staphylococcus aureus in urinary tract infections; prevalence and antimicrobial resistance e8 e8 10.34172/jrip.2022.08 EN Raghad Abdulsalam Khaleel https://orcid.org/0000-0001-5757-5356 Narjes Alfuraiji https://orcid.org/0000-0001-5338-6443 Balsam Waleed Hussain Maadh Fawzi Nassar https://orcid.org/0000-0003-0643-7337 Farnoosh Ebrahimzadeh https://orcid.org/0000-0002-4976-2968 Journal Article 10.34172/jrip.2022.08 2021 04 29 2021 05 20 Introduction: The newly-launched strain of the Staphylococcus aureus, methicillin-resistant S. aureus, is considered the most emerging bacterium in-hospital infections globally. Objectives: The current research focused on the prevalence and virulence features of methicillin-resistant S. aureus (MRSA) bacteria recovered from urinary tract infections (UTIs) cases. Patients and Methods: A total of 710 urine specimens were taken from hospitalized patients who suffered from UTIs. S. aureus was recovered from urine specimens using the microbial culture. S. aureus antimicrobial susceptibility was assessed toward oxacillin and cefoxitin antimicrobial disk to determine the MRSA strains. The polymerase chain reaction (PCR) assessed the distribution of antimicrobial resistance encoding genes. S. aureus antimicrobial resistance was evaluated by disk diffusion. Results: Fifty-five out of 710 (7.7%) urine specimens were positive for the MRSA bacteria. The uppermost antibiotic resistance was obtained against penicillin (100%), ceftaroline (100%), gentamicin (87.2%), erythromycin (76.3%), and ciprofloxacin (69.0%). BlaZ (100%) and tetK (85.4%) had the higher frequency amid examined antimicrobial resistance-encoding genes. Conclusion: The high prevalence of MRSA isolates harboring antimicrobial resistance-encoding genes in the UTIs suggests that diseases caused by them need more expansion healthcare monitoring with essential demand for novel antimicrobials.