Nickan Research Institute Journal of Renal Injury Prevention 2345-2781 11 4 2022 12 01 The effects of sleeve gastrectomy on renal function in diabetic and non-diabetic morbidly obese patients e32028 e32028 10.34172/jrip.2022.32028 EN Zahra Davoudi https://orcid.org/0000-0003-3332-9382 Narges-Sadat Zahed https://orcid.org/0000-0002-2269-6542 Sahab-Sadat Tabatabaei https://orcid.org/0000-0001-8240-1980 Yeganeh Farsi https://orcid.org/0000-0002-4636-6572 Mohsen Soori https://orcid.org/0000-0002-4457-4386 Seyed Hadi Mirhashemi https://orcid.org/0000-0002-0710-4975 Journal Article 10.34172/jrip.2022.32028 2022 02 15 2022 05 19 Introduction: Obesity is associated with albuminuria and impaired renal function. Bariatric surgery improves and resolves diabetes and restores renal function in patients with morbid obesity. Objectives: This study investigates and compares the potential effects of sleeve gastrectomy on improving renal function and albuminuria in diabetic and non-diabetic morbidly obese patients. Patients and Methods: This prospective study included 137 morbidly obese individuals (44 diabetics and 93 non-diabetic) who underwent laparoscopic sleeve gastrectomy. The patients were evaluated clinically (anthropometric measurements) and biochemically before surgery and at one year after surgery. Results: Sleeve gastrectomy significantly decreased weight and body mass index (BMI), improves glycemic parameters, hyperfiltration, and urinary albumin excretion in diabetic and non-diabetic patients (P<0.001). Alterations in C-reactive protein (CRP) levels are strongly associated with albumin-to-creatinine ratio (ACR) decline in diabetic patients. Conclusion: This study showed significant decreases in weight, BMI and glycemic parameters after sleeve gastrectomy in diabetic and non-diabetic individuals, accompanied by the resolution of hyperfiltration, urinary albumin excretion, and improvement of renal function by reduction of systemic inflammation.