Nickan Research Institute Journal of Renal Injury Prevention 2345-2781 12 1 2023 03 01 Potential biomarkers of chronic kidney disease progression among kidney-derived proteins; a review e32040 e32040 10.34172/jrip.2023.32040 EN Sangeetha Prabhu Kademani https://orcid.org/0000-0001-6193-9642 Prabhudas Nelaturi https://orcid.org/0000-0002-0390-3235 Vishnu Bhat https://orcid.org/0000-0002-8856-7348 Sathya Sagar https://orcid.org/0000-0002-2519-7669 Ravikumar Sambandam https://orcid.org/0000-0001-7351-0421 Journal Article 10.34172/jrip.2023.32040 2022 03 05 2023 01 02 The incidence and mortality rate of kidney disease and its progression to end-stage disease have predominantly increased worldwide. Other morbid conditions, such as diabetes and hypertension, are major risk factors for kidney disease. Detection of kidney disease is difficult due to its heterogeneity and complex pathophysiology. Kidney injury and advanced stages of the disease are currently assessed by traditional biomarkers such as serum creatinine, albuminuria, proteinuria and estimated glomerular filtration rate. Numerous biomarkers derived from the kidney involved in endothelial dysfunction, inflammatory processes and tubular cell damage are potential targets for disease progression management. The review summarized potential biomarkers of chronic kidney disease (CKD) to improve patient care in various clinical practices with an increased focus on loss of kidney function.