Nickan Research Institute Journal of Renal Injury Prevention 2345-2781 13 4 2024 12 01 Association of AT1R (A1166C) gene polymorphisms and hypertension: A study in south Indian population and meta-analysis e32197 e32197 10.34172/jrip.2024.32197 EN Amulya Ramakrishnegowda https://orcid.org/0000-0002-7775-0980 Sandhya Suresh https://orcid.org/0000-0001-8821-0579 Ramprasad Elumalai https://orcid.org/0000-0003-2399-1698 Harini Ravi https://orcid.org/0000-0001-5640-3675 Gnanasambandan Ramanathan https://orcid.org/0000-0002-4361-6679 Journal Article 10.34172/jrip.2024.32197 2023 04 30 2023 06 15 Introduction: Hypertension is a multi-factorial disease caused by several etiologies. It has been reported that hypertension has been linked to AT1R A1166C polymorphism, but the previous studies in Indian populations remain controversial. Objectives: In this study, we aimed to investigate the AT1R A1166C gene polymorphism with the risk of hypertension in the south Indian populations. Patients and Methods: The 179 subjects were considered in the association study utilizing polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) genotyping technique, yielding no significant association in the dominant and allelic models P=0.76 and P=0.76 respectively. Additionally, to determine the relationship between the AT1R gene A1166C polymorphism and hypertension in the Indian population, a metaanalysis was conducted. The retrieved seven case-control studies on Indian populations are conducted to determine how strongly genes are associated using the pooled odds ratio (OR) and 95% confidence intervals (CI). Results: The meta-analysis was performed by RevMan software and significant association was observed in the dominant (AA versus AC+CC, P=0.05), recessive (CC versus AA+AC, P=0.02) and allelic (A versus C, P=0.04) models respectively. Conclusion: The ‘C’ allele is statistically associated with an elevated hypertension risk in Indian populations.