Nickan Research Institute Journal of Renal Injury Prevention 2345-2781 14 1 2025 03 01 Renal failure following the administration of proton pump inhibitors; a mini-review article on recent findings e32260 e32260 10.34172/jrip.2024.32260 EN Parisa Tajdini Majid Foroutan https://orcid.org/0000-0002-3691-2365 Journal Article 10.34172/jrip.2024.32260 2023 10 22 2024 01 01 Proton pump inhibitors (PPIs) are frequently administered for the treatment of acid-related disorders such as gastroesophageal reflux disease (GERD). However, there is growing concern about their capability of adverse effects, including renal failure. Several studies have described a relationship between PPI administration and an increased risk of acute kidney injury (AKI) and chronic kidney disease (CKD). The mechanism behind this association is not fully understood, but it may involve changes in renal blood flow and tubular function. The risk of renal failure appears to be higher in patients who use PPIs for extended periods of time or at high doses. It is also higher in patients with pre-existing kidney disease or other risk factors for renal impairment. Clinicians should be aware of the potential risks of PPI use and consider alternative treatment options in patients with renal impairment or other risk factors for AKI or CKD. Regular monitoring of kidney function may also be warranted in patients on long-term PPI therapy.