Nickan Research Institute Journal of Renal Injury Prevention 2345-2781 14 2 2025 06 01 Emerging trends in renoprotective agents; a pharmacological perspective for world kidney day 2025 e38444 e38444 10.34172/jrip.2025.38444 EN Zahra Bazargani https://orcid.org/0000-0003-1943-5752 Journal Article 10.34172/jrip.2025.38444 2024 12 14 2025 02 12 The management of kidney disease is witnessing a paradigm shift, driven by the emergence of innovative renoprotective agents and a deeper understanding of disease mechanisms. This review highlights the latest pharmacological advancements and therapeutic strategies aimed at preserving renal function and improving outcomes for patients with kidney disease. Key developments include the exploration of cell therapy and regenerative medicine, particularly the use of renal progenitor cells to repair damaged kidney tissue, and the groundbreaking application of kidney organoids, which offer new insights into disease pathology and personalized treatment approaches. Additionally, the shift toward combination therapies, such as the concurrent use of SGLT2 (sodium-glucose cotransporter 2) inhibitors with other kidney-protective agents, demonstrates significant promise in addressing the multifactorial nature of kidney disease progression. Beyond pharmacological interventions, the integration of lifestyle modifications, including dietary adjustments, physical activity, and risk factor management remains fundamental to both prevention and treatment. As we commemorate world kidney day, this review also emphasizes the importance of a multidisciplinary approach, combining cutting-edge pharmacological innovations with holistic lifestyle strategies to combat the global burden of kidney disease and improve patient outcomes.