Nickan Research Institute Journal of Renal Injury Prevention 2345-2781 15 2 2026 06 01 Association between cardiometabolic index and kidney stones; a systematic review and meta-analysis e38693 e38693 10.34172/jrip.2025.38693 EN Sina Salem Ahim https://orcid.org/0009-0008-2452-434X Amir Heidari https://orcid.org/0000-0001-9802-7487 Leila Ashrafi https://orcid.org/0000-0001-5204-2825 Mohammad Rostamzadeh https://orcid.org/0009-0004-6817-7467 Negar Jafari https://orcid.org/0000-0002-6249-2587 Zahra Eydizadeh https://orcid.org/0009-0005-5411-6417 Rasoul Jafari Arismani https://orcid.org/0000-0001-7440-0507 Roozbeh Roohinezhad https://orcid.org/0000-0002-0866-2047 Abdolmohammad Ranjbar https://orcid.org/0000-0003-2235-2149 Mohammad Parsa Mahjoob https://orcid.org/0000-0003-1269-3134 Sara Rashki Ghalehno https://orcid.org/0000-0002-7638-2290 Journal Article 10.34172/jrip.2025.38693 2025 08 09 2025 11 04 Introduction: T Kidney stone is a common urological disease, and high values of cardiometabolic index (CMI) are primarily linked with metabolic disorders, including obesity, insulin resistance and metabolic syndrome, which are associated with the formation of kidney stones (nephrolithiasis). Accordingly, our study aimed to investigate the relationship between high CMI values and the risk of kidney stones. Materials and Methods: Databases such as Web of Science, Cochrane, Scopus, PubMed, Embase, and Google Scholar Search Engine were conducted for articles published until August 27, 2025. Data were analyzed using STATA 14. Tests with P values<0.05 were considered statistically significant. Results: Results revealed that high CMI levels increased the risk of kidney stones (OR=1.39, 95% CI: 1.31, 1.47). As high CMI values in the second one-third (OR=1.38, 95% CI: 1.25, 1.52), third one-third (OR=1.35, 95% CI: 1.22, 1.49), second quartile (OR=1.31, 95% CI: 1.11, 1.56), third quartile (OR=1.45, 95% CI: 1.23, 1.71), and fourth quartile (OR=1.57, 95% CI: 1.33, 1.85) increased the risk of kidney stones. Additionally, high CMI levels increased the risk of kidney stones in men (OR=1.28, 95% CI: 1.16, 1.42), women (OR=1.28, 95% CI: 1.18, 1.39), patients with BMIs 25-30 (OR=1.21, 95% CI: 1.08, 1.35), patients with BMIs ≥ 30 (OR=1.25, 95% CI: 1.12, 1.39), patients younger than 60 (OR=1.24, 95% CI: 1.13, 1.37), patients older than 60 (OR=1.36, 95% CI: 1.26, 1.48), and diabetic individuals (OR=1.52, 95% CI: 1.36, 1.70). Conclusion: High CMI levels increased the risk of kidney stone formation by 39%. The risk was similar in men and women; however, the risk of kidney stones increased with the patients’ age. Furthermore, obese individuals were at a higher risk compared with those who were overweight. Registration: This study has been compiled in accordance with the PRISMA checklist, and its protocol was registered on the PROSPERO (ID: CRD420251141496) and Research Registry (UIN: reviewregistry2044) websites.