Nickan Research Institute Journal of Renal Injury Prevention 2345-2781 7 1 2018 03 01 Epithelial and endothelial mesenchymal transition and their role in diabetic kidney disease 1 6 10.15171/jrip.2018.01 EN Farahnaz Dadras Vida Sheikh Farhad Khoshjou Journal Article 10.15171/jrip.2018.01 2017 07 03 2017 09 10 Diabetic nephropathy (DN) is the main cause of end-stage renal disease. On the other hand, there are a couple of evidences, including human studies, which prove the role of epithelial mesenchymal transition (EMT) in pathophysiology of DN. EMT is characterized by loss of epithelial proteins and gain of mesenchymal markers. EMT is induced via three main conduit; TGFβ/Smad, integrin /ILK as well as Wnt/β-catenin pathways. Besides, numerous studies illustrated how drugs and agents can modify this phenomenon. On the other hand, endothelial mesenchymal transition (EndoMT) has a well-known role in pathophysiology of diabetic nephropathy which has been studied in animal and human. Here, several drugs and modifiers which have been studied to ffigure out if they can amend nature of EMT or EndoMT are reported briefly