Nickan Research Institute Journal of Renal Injury Prevention 2345-2781 8 3 2019 09 01 The effect of artichoke leaf extract supplementation on lipid profile of chronic kidney disease patients; a double-blind, randomized clinical trial 225 229 10.15171/jrip.2019.42 EN Seyed Mansour Gatmiri https://orcid.org/0000-0002-1920-771X Ebrahim Khadem https://orcid.org/0000-0002-4926-9436 Toktam Fakhrian Mohammad Kamalinejad Hamed Hosseini Fereshteh Ghorat Azam Alamdari https://orcid.org/0000-0002-5319-8183 Neda Naderi https://orcid.org/0000-0002-9117-9610 Journal Article 10.15171/jrip.2019.42 2019 04 03 2019 06 19 Introduction: Hyperlipidemia is considered a prominent risk factor for coronary heart disease. Coronary heart disease is the most common cause of mortality and morbidity in chronic kidney disease (CKD) patients. Objectives: The aim of this study was to evaluate the effects of artichoke leaf extract (ALE) supplementation on the lipid profile of CKD patients. Patients and Methods: A randomized, double-blind, placebo-controlled clinical trial was conducted in 38 CKD subjects (GFR<60 and >15 mL/min/1.73 m2 ) with hypercholesterolemia (total cholesterol ≥ 200 mg/dL or low-density lipoprotein cholesterol [LDL-C] ≥ 110 mg/dL). The intervention group received an artichoke capsule (320 mg) and an indistinguishable placebo was given to the control group twice daily for 6 weeks. Lipid profile and appetite were assessed at week 8 and the results were compared with the baseline data. Results: ALE supplementation was correlated with a statistically significant decrease in mean total cholesterol (P=0.028) and LDL-C (P=0.005) compared to the control group. The two groups did not show a significant difference in high-density lipoprotein-cholesterol (P=0.071) and triglyceride levels (P=0.22). There was a statistically significant difference in appetite between the two groups (P=0.016). Conclusion: This randomized controlled trial demonstrated that consumption of ALE supplement may improve appetite and lipid profile in CKD patients.