eISSN: 2345-2781  



First published online: 01 Jun 2015
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J Renal Inj Prev. 2015;4(2).
doi: 10.12861/jrip.2015.07
PMID: 26060834
PMCID: PMC4459725

Review Article

Diabetes and end-stage renal disease; a review article on new concepts

Seyed Bahman Ghaderian 1, Fatemeh Hayati 2, Shokouh Shayanpour 2, Seyed Seifollah Beladi Mousavi 2 *

1 Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Chronic Renal Failure Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
*Corresponding author: Seyed Seifollah Beladi Mousavi, Chronic Renal Failure Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Email: Beladimusavi@yahoo.com

Abstract

It is well established that diabetic nephropathy is the most common cause or in combination with hypertensive nephropathy are the most common causes of end-stage renal disease (ESRD) in developed and developing countries. For this review, we used a variety of sources by searching through PubMed, Embase, Scopus, Current Content and Iran Medex from January 1990 up to December 2014. Manuscripts published in English and Persian languages, as full-text articles, and or as abstract were included in the study. Patient survival in diabetics on maintenance renal replacement therapy including hemodialysis (HD), peritoneal dialysis (PD) and kidney transplantation is significantly lower than that seen in nondiabetics with ESRD. The poor prognosis of diabetic patients with ESRD is partly due to presence of significant cardiovascular disease, problems with vascular access, more susceptible to infections, foot ulcer, and hemodynamic instability during HD. Although, many complications related to kidney transplantation may occur in diabetic ESRD patients, multiple studies have found that the kidney transplantation is the preferred renal replacement therapy for diabetic patients with ESRD and it is associated with a much better survival and quality of life than dialysis among these patients.

Implication for health policy/practice/research/medical education:

It is well established that diabetic nephropathy and hypertensive nephropathy are the leading cause of end-stage renal disease (ESRD) in developed and developing countries reflects the catastrophic squeals of these two silent killers. On the other hand, ESRD is a worldwide public health problem with an enormous financial burden for healthcare systems.

Please cite this paper as: Ghaderian SB, Hayati F, Shayanpour S, Beladi Mousavi SS. Diabetes and end-stage renal disease; a review article on new concepts. J Renal Inj Prev. 2015; 4(2): 28-33. DOI: 10.12861/jrip.2015.07

 

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