eISSN: 2345-2781  
J Renal Inj Prev. 2017;6(4):259-263.
doi: 10.15171/jrip.2017.49

Scopus id: 85040735414

Original Article

Comparing the efficacy of desmopressin and oxybutynin combination therapy and desmopressin monotherapy in children with primary nocturnal enuresis; a randomized clinical trial

Yalda Ravanshad 1, Anoush Azarfar 2, Afshin Ghalegolab-Behbahan 3, Fakhrosadat Mortazavi 3, Sonia Ahmadzadeh 4, Fereshteh Ghorat 5, Samira Foji 6, Elham Iziy 5,7, Marjan Vejdan 8 *

1 Clinical Research Development Center, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2 Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3 Department of Pediatrics, Pediatrics Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
4 Department of Pediatrics Nephrology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
5 Traditional and Complementary Medicine Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran
6 Faculty Member School of Paramedical, Sabzevar University of Medical Sciences, Sabzevar, Iran
7 Department of Biology, Faculty of Sciences, Islamic Azad University, Sciences and Researches Branch, Tehran, Iran
8 Iranian Research Center on Healthy Aging, Sabzevar University of Medical Sciences, Sabzevar, Iran
*Corresponding author: Marjan Vejdani, Email: marjanvejdani1986@gmail.com

Abstract

Introduction: Nocturnal enuresis is known as the most common developmental problems of childhood which has often a familial basis. It is usually benign and gradually disappears with age.

Objectives: This study was conducted on children with primary nocturnal enuresis to compare the efficacy of desmopressin and oxybutynin combination therapy with desmopressin monotherapy.

Patients and Methods: This clinical trial was conducted on 59 patients (age range; 5 to 15 years) with primary nocturnal enuresis who had referred to our center in Tabriz in 2012. The participants were divided into two groups as group 1 (30 participants) and group 2 (29 subjects). For three months, one group received desmopressin and oxybutynin and the other group received desmopressin alone. Descriptive statistics (mean ± SD and frequency) and chi-square test was conducted.

Results: In the group treated only with desmopressin, 72.4% of the participants were completely cured in 1 month and 44.8% in 3 months. In the group treated with combination of desmopressin and oxybutynin, 83.34% were cured in 1 month and 86.7% in 3 months.

Conclusion: Desmopressin and oxybutynin combination therapy is more effective than desmopressin monotherapy for treating children with enuresis.

Implication for health policy/practice/research/medical education:

Desmopressin and oxybutynin combination therapy is more effective than desmopressin monotherapy for treating children with enuresis.

Please cite this paper as: Ravanshad Y, Azarfar A, Ghalegolab-Behbahan A, Mortazavi F, Ahmadzadeh S, Ghorat F, et al. Comparing the efficacy of desmopressin and oxybutynin combination therapy and desmopressin monotherapy in children with primary nocturnal enuresis; a randomized clinical trial. J Renal Inj Prev. 2017;6(4):259-263. DOI: 10.15171/jrip.2017.49.

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