Implication for health policy/practice/research/medical education:
Renal injury associated with ischemia/reperfusion results from a dynamic process involving inflammation and some mediators in a complex interaction. Formation of oxidative stress and lipid peroxidation seems to be major factors which promotes the inflammation process during ischemia/reperfusion injury. A better understanding of the pathophysiology and therapeutic approach underlying the functional defects found in ischemic acute renal failure will also require that we take into account the complexity of illness.
Please cite this paper as: Malek M, Nematbakhsh M. Renal ischemia/reperfusion injury; from pathophysiology to treatment. J Renal Inj Prev. 2015; 4(2): 20-27. DOI: 10.12861/jrip.2015.06