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Submitted: 15 Feb 2022
Accepted: 19 May 2022
ePublished: 31 May 2022
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J Renal Inj Prev. 2022;11(4): e32028.
doi: 10.34172/jrip.2022.32028
  Abstract View: 196
  PDF Download: 54

Original

The effects of sleeve gastrectomy on renal function in diabetic and non-diabetic morbidly obese patients

Zahra Davoudi 1 ORCID logo, Narges-Sadat Zahed 2 ORCID logo, Sahab-Sadat Tabatabaei 3 ORCID logo, Yeganeh Farsi 4 ORCID logo, Mohsen Soori 5 ORCID logo, Seyed Hadi Mirhashemi 5* ORCID logo

1 Department of Internal Medicine, Endocrinology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Department of Internal Medicine, Nephrology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Student’s Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5 Department of Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
*Corresponding Author: Corresponding author: Seyed Hadi Mirhashemi, Email: , Email: sh.mirhashemi@sbmu.ac.ir

Abstract

Introduction: Obesity is associated with albuminuria and impaired renal function. Bariatric surgery improves and resolves diabetes and restores renal function in patients with morbid obesity.

Objectives: This study investigates and compares the potential effects of sleeve gastrectomy on improving renal function and albuminuria in diabetic and non-diabetic morbidly obese patients.

Patients and Methods: This prospective study included 137 morbidly obese individuals (44 diabetics and 93 non-diabetic) who underwent laparoscopic sleeve gastrectomy. The patients were evaluated clinically (anthropometric measurements) and biochemically before surgery and at one year after surgery.

Results: Sleeve gastrectomy significantly decreased weight and body mass index (BMI), improves glycemic parameters, hyperfiltration, and urinary albumin excretion in diabetic and non-diabetic patients (P<0.001). Alterations in C-reactive protein (CRP) levels are strongly associated with albumin-to-creatinine ratio (ACR) decline in diabetic patients.

Conclusion: This study showed significant decreases in weight, BMI and glycemic parameters after sleeve gastrectomy in diabetic and non-diabetic individuals, accompanied by the resolution of hyperfiltration, urinary albumin excretion, and improvement of renal function by reduction of systemic inflammation.


Implication for health policy/practice/research/medical education:

In a sleeve gastrectomy on 137 morbidly obese patients (44 diabetics and 93 non-diabetic), we found a significant decreases in weight, body mass index (BMI), and glycemic parameters after sleeve gastrectomy in diabetic and non-diabetic patients, accompanied by the resolution of hyperfiltration, urinary albumin excretion, and improvement of renal function by reduction of systemic inflammation. Therefore, sleeve gastrectomy would be beneficial in patients with diabetes and BMI greater than 35, restores and improves their renal function.

Please cite this paper as: Davoudi Z, Sadat Zahed N, Sadat Tabatabaei S, Farsi Y, Soori M, Mirhashemi SH. The effects of sleeve gastrectomy on renal function in diabetic and non-diabetic morbidly obese patients. J Renal Inj Prev. 2022; 11(4): e32028. doi: 10.34172/jrip.2022.32028.

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