Submitted: 13 Mar 2019
Accepted: 27 May 2019
ePublished: 14 Jun 2019
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J Renal Inj Prev. 2019;8(3): 243-246.
doi: 10.15171/jrip.2019.46
  Abstract View: 671
  PDF Download: 346

Letter to Editor

Influence of zinc deficiency on one year recurrence in children with nephrotic syndrome

Fatemeh Ghafoorimehr 1, Mastaneh Moghtaderi 1 * ORCID logo, Behnaz Bazargani 1, Dariush Fahimi 1, Arash Abbasi 1

1 Children Medical Center Hospital, Tehran University of Medical Science, Tehran, Iran


Introduction: Relapses in children with steroid sensitive nephrotic syndrome (SSNS) are common and sometimes triggered by various infections. Low zinc levels have been described in children with nephrotic states. It is supposed to that zinc deficiency might lead to dysregulation of immune system and an increased risk of infection.

Objectives: This study sought to examine whether the plasma level of zinc in nephrotic patients is related to the number of relapses in these patients.

Patients and Methods: Forty-three children aged 1-10 years were entered in this study. Baseline data including age, serum zinc level, number of relapses during one year was recorded. The t test and chi-square tests were used to compare the mean values and proportions respectively with significant P value (P < 0.05).

Results: Forty-three children with storied sensitive nephrotic syndrome enrolled in this study. Twenty-three (53.5%) of them were male and 20 (46.5%) were female. Around 74.4 % of patients experienced relapses of nephrotic syndrome in one-year period. There was a significant relation between zinc deficiency and recurrence rate.

Conclusion: Zinc deficiency is common in children suffering from nephrotic syndrome and is related to recurrence of relapses in these patients.

Keywords: Nephrotic syndrome, Zinc deficiency, Recurrence, Children

Implication for health policy/practice/research/medical education:

Our study on 43 children with storied sensitive nephrotic syndrome showed that recurrence in nephrotic patients have a relationship between low plasma zinc levels. We suggest zinc supplementation in these patients along with standard steroid therapy.

Please cite this paper as: Gafoorimehr F , Moghtaderi M, Bazargani B, Fahimi D, Abbasi A. Influence of zinc deficiency on one year recurrences in children with nephrotic syndrome. J Renal Inj Prev. 2019;8(3):243-246. DOI: 10.15171/jrip.2019.46.

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