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Submitted: 27 Oct 2019
Accepted: 10 Jan 2020
ePublished: 03 Feb 2020
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J Renal Inj Prev. 2021;10(1): e02.
doi: 10.34172/jrip.2021.02
  Abstract View: 95
  PDF Download: 31

Original Article

The association of serum uromodulin with allograft function and risk of urinary tract infection in kidney transplant recipients

Vahideh Ebrahimzadeh Attari 1 ORCID logo, Arezoo Maddah 2, Zahra Shahveghar Asl 3 ORCID logo, Mahsa Jalili 4 ORCID logo, Mohammad Reza Ardalan 2 * , Saman Mokari 2

1 Maragheh University of Medical Sciences, Maragheh, Iran
2 Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3 Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
4 Cell, Molecular Biology and Genomics Group, Department of Biology, Norwegian University of Science and Technology, Trondheim, Norway
*Corresponding author: Prof. Mohammad Reza Ardalan, Email: ardalan34@yahoo.com, ardalanm@tbzmed.ac.ir

Abstract

Introduction: There is some evidence to suggest that low levels of uromodulin in urine and serum are associated with decreased renal function and increased mortality risk.

Objectives: This study is designed to measure circulating uromodulin levels and explore their relationship to urinary tract infection and renal function in kidney transplant recipients.

Patients and Methods: In this cross-sectional study, 90 eligible kidney transplant recipients were evaluated 6–12 months of post-transplantation. Fasting blood samples were taken to determine the serum level of uromodulin with urea, creatinine, and other biochemical characteristics. Urine samples were taken for analysis and culture. Kidney function was estimated based on the chronic kidney disease epidemiology collaboration (CKD-EPI) creatinine equation and the modification of diet in renal disease (MDRD) equation.

Results: Patients’ serum uromodulin levels were significantly correlated with their serum creatinine (P = 0.024) and estimated glomerular filtration rate by the EPI equation (eGFR-EPI, P = 0.038). There was no significant association between serum uromodulin levels and incidence of urinary tract infection of post-transplantation (P > 0.05).

Conclusion: Serum and urine uromodulin levels may be regarded as the predictive indicators of renal function. However, given the lack of studies on the association between serum uromodulin levels and urinary tract infection risks in kidney transplant recipients, further research is needed to clarify uromodulin’s protective effect against urinary tract infection.

Keywords: Uromodulin, Urinary tract infections, Kidney function, Kidney transplantation, Chronic kidney disease, Glomerular filtration rate, Endstage renal disease

Implication for health policy/practice/research/medical education:

In a study on 90 eligible kidney transplant recipients, we found serum uromodulin levels are significantly related to serum creatinine levels and estimated glomerular filtration rate, but there is no significant association between serum uromodulin levels and urinary tract infection incidence.

Please cite this paper as: Ebrahimzadeh Attari V, Maddah A, Shahveghar Asl Z, Jalili M, Ardalan ME, Mokari S. The association of serum uromodulin with allograft function and risk of urinary tract infection in kidney transplant recipients. J Renal Inj Prev. 2021; 10(1): e02. doi: 10.34172/jrip.2021.02.

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