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Submitted: 06 Mar 2019
Accepted: 13 May 2019
ePublished: 09 Jun 2019
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J Renal Inj Prev. 2019;8(3): 199-203.
doi: 10.15171/jrip.2019.37
  Abstract View: 664
  PDF Download: 402

Original

APOL1 renal risk alleles in patients on chronic hemodialysis in Northwest of Iran

Sepideh Zununi Vahed 1 ORCID logo, Ehsan Rikhtegar 1, Vahideh Ebrahimzadeh Attari 2 ORCID logo, Mehdi Haghi 3, Ramin Tolouian 4 ORCID logo, Mohammadali Mohajel Shoja 5, Mohammadreza Ardalan 1 *

1 Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 Maragheh University of Medical Sciences, Maragheh, Iran
3 Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
4 Division of Nephrology, University of Arizona, Tucson, AZ, USA
5 Department of Surgery, University of Texas Medical Branch, Galveston, Texas, USA
*Corresponding author: Prof. Mohammadreza Ardalan, Email: ardalan34@yahoo.com and ardalanm@tbzmed.ac.ir

Abstract

Introduction: Apolipoprotein L1 (APOL1) gene’s risk variants located on chromosome 22 are newly discovered factors for the development of chronic renal failure among African-American. These risk alleles were developed on the African continent as an evolutionary defense against sleep sickness due to Trypanosoma brucei rhodesiense and then spread with human migrations.

Objectives: In the present study, we sought to examine these risk variants in a group of hemodialysis patients of Northwest of Iran.

Patients and Methods: Two hundred patients receiving hemodialysis in different centers of the city (Tabriz in Northwest of Iran) were allocated randomly from a total number of 825 patients. The assessment of APOL1 polymorphisms (rs73885319, rs60910145, and rs71785313) was conducted using polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) method. Patients’ demographic data, history, and their biochemical parameters were recorded based on their last measurement.

Results: No proposed renal risk variants of APOL1 gene in our hemodialysis population were found. All the participants had a wild genotype.

Conclusion: The results of our study match with reports from Europe and Asia. In the paleoanthropological point of view, our results do not support African human migration hypothesis.  

Keywords: Chronic kidney disease, End-stage renal disease, Hemodialysis, Chronic renal failure, African-American, Apolipoprotein L1

Implication for health policy/practice/research/medical education:

The appearance of renal risk variants of APOL1 gene (G1, and G2) protect the host against African sleep sleekness; however, predispose carriers to kidney disease. In the present study, we did not find any of these variants in a group of hemodialysis population.

Please cite this paper as: Zununi Vahed S, Rikhtegar E, Ebrahimzadeh V, Haghi M, Tolouian R, Mohajel Shoja M, et al. APOL1 renal risk alleles in patients on chronic hemodialysis in Northwest of Iran. J Renal Inj Prev. 2019; 8(3): 199-203. DOI: 10.15171/ jrip.2019.37.

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