Submitted: 06 Mar 2019
Accepted: 13 May 2019
First published online: 09 Jun 2019
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J Renal Inj Prev. 2019;8(3):199-203.
doi: 10.15171/jrip.2019.37
  Abstract View: 300
  PDF Download: 232

Original

APOL1 renal risk alleles in patients on chronic hemodialysis in Northwest of Iran

Sepideh Zununi Vahed 1 ORCiD, Ehsan Rikhtegar 1, Vahideh Ebrahimzadeh Attari 2 ORCiD, Mehdi Haghi 3, Ramin Tolouian 4 ORCiD, Mohammadali Mohajel Shoja 5, Mohammadreza Ardalan 1 *

1 Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 Maragheh University of Medical Sciences, Maragheh, Iran
3 Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
4 Division of Nephrology, University of Arizona, Tucson, AZ, USA
5 Department of Surgery, University of Texas Medical Branch, Galveston, Texas, USA
*Corresponding author: Prof. Mohammadreza Ardalan, Email: ardalan34@yahoo.com and Email: ardalanm@tbzmed.ac.ir

Article

Introduction: Apolipoprotein L1 (APOL1) gene’s risk variants located on chromosome 22 are newly discovered factors for the development of chronic renal failure among African-American. These risk alleles were developed on the African continent as an evolutionary defense against sleep sickness due to Trypanosoma brucei rhodesiense and then spread with human migrations.

Objectives: In the present study, we sought to examine these risk variants in a group of hemodialysis patients of Northwest of Iran.

Patients and Methods: Two hundred patients receiving hemodialysis in different centers of the city (Tabriz in Northwest of Iran) were allocated randomly from a total number of 825 patients. The assessment of APOL1 polymorphisms (rs73885319, rs60910145, and rs71785313) was conducted using polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) method. Patients’ demographic data, history, and their biochemical parameters were recorded based on their last measurement.

Results: No proposed renal risk variants of APOL1 gene in our hemodialysis population were found. All the participants had a wild genotype.

Conclusion: The results of our study match with reports from Europe and Asia. In the paleoanthropological point of view, our results do not support African human migration hypothesis.

Implication for health policy/practice/research/medical education:

The appearance of renal risk variants of APOL1 gene (G1, and G2) protect the host against African sleep sleekness; however, predispose carriers to kidney disease. In the present study, we did not find any of these variants in a group of hemodialysis population.

Please cite this paper as: Zununi Vahed S, Rikhtegar E, Ebrahimzadeh V, Haghi M, Tolouian R, Mohajel Shoja M, et al. APOL1 renal risk alleles in patients on chronic hemodialysis in Northwest of Iran. J Renal Inj Prev. 2019; 8(3): 199-203. DOI: 10.15171/ jrip.2019.37.

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