Submitted: 06 Sep 2019
Accepted: 20 Jan 2019
First published online: 28 Feb 2019
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J Renal Inj Prev. 2019;8(3):230-234.
doi: 10.15171/jrip.2019.43
  Abstract View: 321
  PDF Download: 244


Combined effect of cadmium and noise on rat’s kidney 

Ameneh Golbaghi 1 ORCiD, Behzad Fouladi Dehagi 1 ORCiD, Massumeh Ahmadizadeh 1,2 * ORCiD

1 Department of Occupational Health Engineering, School of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
*Corresponding author: Massumeh Ahmadizadeh, Ph.D, Email: Email:


Introduction: Recently, the consequence of chemical industries and noise on human health is the update subject for researchers. There are many reports published about nephrotoxicity of noise and cadmium alone.

Objectives: The main aim of this study was to detect the combined consequence of noise and cadmium on renal function.

Materials and Methods: Forty adult male rats were put into eight groups in random order (n=5). Groups 1 control, group 2 exposed to 90 dB (decibels) noise, groups 3- 5 received (intraperitoneal; ip) cadmium chloride (CdCl2) at doses of 1,2,3 mg/kg and group 6-8 pretreated with CdCl2 at doses of 1, 2, and 3 mg/kg 30 minutes before exposing to 90 dB noise. The exercise was repeated for seven consecutive days. Animals were killed 24 hours afterwards. Blood urea nitrogen (BUN) and creatinine (Cr) levels were analyzed. Kidney tissues were excised for measuring malondialdehyde (MDA) and glutathione (GSH) concentrations.

Results: There was significant rise on the levels of BUN, Cr and MDA. Additionally, a decrease on the level of GSH in rats that were exposed to noise or cadmium alone or combined to noise and cadmium was detected. Significant elevation of BUN, Cr, MDA and depletion of GSH were also noted in cadmium-treated rats compared to those in the animals co-exposed to cadmium and noise.

Conclusion: This study shows that exposed rats to cadmium and/or noise caused renal function impairment. Production of oxidative stress is responsible for cadmium or noise induced nephrotoxicity. However, co-exposure of cadmium and noise reduced nephrotoxicity of cadmium. The possible explanation for noises suppressing cadmium nephrotoxicity is that noise may enhance excretion and/or induced redistribution and depleted accumulation of cadmium in the kidney.

Implication for health policy/practice/research/medical education:

Current investigation represented interaction of cadmium and noise-induced toxicity in rat’s kidney. This investigation was asserted an exposure to either cadmium or noise is known to compromise human health. Both agents induced renal function impairment and produced oxidative stress. However, noise caused suppression of cadmium nephrotoxicity. The mechanism by which noise decreased cadmium nephrotoxicity may be due to noise enhances cadmium excretion and/or noise-induced redistribution and gathering of cadmium in other regions of the body.

Please cite this paper as: Golbaghi A, Fouladi Dehagi B, Ahmadizadeh M. Combined effect of cadmium and noise on rat’s kidney. J Renal Inj Prev. 2019;8(3):230-234. DOI: 10.15171/jrip.2019.43.

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