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ePublished: 01 Mar 2013
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J Renal Inj Prev. 2013;2(1): 5-6.
doi: 10.12861/jrip.2013.03
PMID: 25340112
PMCID: PMC4205999
  Abstract View: 3241
  PDF Download: 1965

Commentary

Protection of renal tubules against gentamicin induced nephrotoxicity

Majid Tavafi 1*

1 Department of anatomy, Faculty of Medicine, Lorestan University of Medical sciences, Khoram Abad, Iran
*Corresponding Author: *Corresponding author: Dr. Majid Tavafi, Department of anatomy, Faculty of Medicine, Lorestan University of Medical sciences, Khoram Abad, Iran., Email: mtavafi@yahoo.com

Abstract

Implication for health policy/practice/research/medical education:It seems that renal tubular damages in acute renal failure involved in gentamicin nephrotoxicity or ischemia/reperfusion mainly induced by increasing of reactive oxygen species (oxidative stress). According to this attitude, many researchers have been used different antioxidant agents in combat with gentamicin nephrotoxicity. Treatment of animal with metformin against gentamicin revealed that gentamicin might be induced renal tubular damages via energy depletion in renal tubular cells besides inducing of oxidative stress. More studies are needed to clarify renal protective effect of adenosine monophosphate-activated protein kinase (AMPK) activator such as metformin in combat with gentamicin nephrotoxicity.

Please cite this paper as: Tavafi M. Protection of renal tubules against gentamicin induced nephrotoxicity. J Ren Inj Prev 2013; 2(1): 5-6.
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