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ePublished: 01 Jun 2013
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J Renal Inj Prev. 2013;2(2): 59-62.
doi: 10.12861/jrip.2013.20
PMID: 25340129
PMCID: PMC4206008
  Abstract View: 2522
  PDF Download: 1510

Mini-Review

Complexity of diabetic nephropathy pathogenesis and design of investigations

Majid Tavafi 1*

1 Department of Anatomy, Faculty of Medicine, Lorestan University of Medical sciences, Khoram Abad, Iran.
*Corresponding Author: *Corresponding author: Dr. Majid Tavafi, Department of Anatomy, Faculty of Medicine, Lorestan University of Medical sciences, Khoram Abad, Iran. , Email: mtavafi@yahoo.com

Abstract

Diabetic nephropathy (DN) pathogenesis is very complex and multifactorial. There are several mechanisms or pathways that hyperglycemia leads to renal injuries. Each pathway makes renal injuries via several mediators. Some mediators are common between the pathways such as reactive oxygen species (ROS) and TGF-β and there are many overlaps and interference between the pathways. This review summarized complexity of DN pathogenesis and overlaps or interfering of mediators between the pathogenesis pathways. Besides, in the review suggested new designs of researches based on this complexity pathogenesis. The pathogenesis of DN is certainly very complex and multifactorial. From the overview of molecular mechanisms of DN pathogenesis, there are many pathways and many mediators with many interferences and overlaps between them. The focal point of this pathogenesis still unknown but it seems that RAAS system, oxidative stress and TGF-β relatively are common between these complex tangle webs of pathogenesis.

Implication for health policy/practice/research/medical education
Diabetic nephropathy (DN) pathogenesis is very complex and multifactorial. There are several mechanisms or pathways that hyperglycemia leads to renal injuries. Each pathway makes renal injuries via several mediators. Some mediators are common between the pathways such as reactive oxygen species (ROS) and TGF-β and there are many overlaps and interference between the pathways. This review summarized complexity of DN pathogenesis and overlaps or interfering of mediators between the pathogenesis pathways.

Please cite this paper as: Tavafi M. Complexity of diabetic nephropathy pathogenesis and design of investigations. J Ren Inj Prev 2013; 2(1): 59-62.
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