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ePublished: 01 Sep 2013
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J Renal Inj Prev. 2013;2(3): 97-101.
doi: 10.12861/jrip.2013.31
PMID: 25340140
PMCID: PMC4206021
  Abstract View: 3276
  PDF Download: 1924

Original Article

AT2R -1332 G:A polymorphism and diabetic nephropathy in type 2 diabetes mellitus patients

Zohreh Rahimi 1,2, Omid Mansouri Zaveleh 3, Ziba Rahimi 1, Ardeshir Abbasi 3

1 Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
2 Department of Biochemistry, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran
3 Department of Biochemistry, Sanandaj Science and Research Branch, Islamic Azad University, Sanandaj, Iran
*Corresponding Author:

Abstract

Introduction: The rennin-angiotensin system (RAS) plays a central role in the regulation of sodium metabolism, vascular tone, blood pressure, renal hemodynamics, and vascular modeling and is activated by hyperglycemiaObjectives: In the present study the influence of AT2R -1332 G:A polymorphism on the risk of T2DM and its complications in a population from Western Iran has been investigated.Patients and Methods: In a case-control study, 70 individuals with type 2 diabetes mellitus (T2DM) including normo-, micro- and macro-albuminuric patients and 112 healthy subjects from the Kermanshah province were studied to investigate the association between the angiotensin type 2 receptor (AT2R) -1332 G:A variants with the risk of T2DM and its complications. The genotypes of the AT2R were detected using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Analysis of AT2R -1332 G:A polymorphism indicated the absence of association between this polymorphism with T2DM and diabetic nephropathy.Results: Analysis of AT2R -1332 G:A polymorphism indicated the absence of association between this polymorphism with T2DM and diabetic nephropathy. In females with diabetic nephropathy a significantly higher frequency of AA genotype (50%) was detected compared to those without nephropathy (13.3%, p=0.015). The presence of A allele of AT2R was associated with significantly (p=0.029) increased risk of coronary artery disease (CAD) in diabetic patients without nephropathy.Conclusion: Our study indicated an association between the AT2R -1332 G:A polymorphism and the risk of diabetic nephropathy in females only. Also, the A allele was associated with the risk of CAD in those diabetic patients without nephropathy.

Implication for health policy/practice/research/medical education:
In a case-control study on 70 individuals with type 2 diabetes mellitus, we found that the presence of A allele of AT2R is associated with the risk of coronary artery disease in diabetic patients without nephropathy.

Please cite this paper as: Rahimi Z, Mansouri Zaveleh O, Rahimi Z, Abbasi A. AT2R -1332 G:A polymorphism and diabetic nephropathy in type 2 diabetes mellitus patients. J Ren Inj Prev 2013; 2: 97-101.
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