Ali Lanewala
1*, Muhammed Mubarak
21 Pediatric Nephrology Department, Sindh Institute of Urology and Transplantation (SIUT), Karachi, Pakistan
2 Histopathology Department, Sindh Institute of Urology and Transplantation (SIUT), Karachi, Pakistan
*Corresponding Author: *Corresponding author: Dr. Ali Lanewala, Pediatric Nephrology Department, Sindh Institute of Urology and Transplantation, Civil Hospital, Karachi, Pakistan. Phone No. 9221 94989172, Fax No. 9221 32726165. , Email:
alilanewala@yahoo.com
Abstract
Implication for health policy/practice/research/medical education IgM nephropathy (IgMN) is a controversial clinicoimmunopathologic entity in the arena of primary glomerulopathies. Recently, many clinicopathological studies have been published, but there is severe lack of information on etiopathogenesis of the condition. A recent study has found that naturally occurring IgM antibody is pathogenic and plays a role in causing damage in animal models and focal segmental glomerulosclerosis (FSGS). This study provides an important stimulus for basic research focused on elucidating the pathophysiology of IgMN.