Hamid Nasri
1, Saeed Behradmanesh
2, Ali Ahmadi
3, Azar Baradaran
4, Parto Nasri
4, Mahmoud Rafieian-Kopaei
2*1 Department of Nephrology, Division of Nephropathology, Isfahan University of Medical Sciences, Isfahan, Iran
2 Medical Plants Research Center, Shahrekord University of Medical Sciences, Sharekord, Iran
3 Department of Epidemiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran
*Corresponding Author: *Corresponding author: Prof. Mahmoud Rafieian-kopaei, Medical Plants Research Center, Shahrekord University of Medical Sciences, Sharekord, Iran. , Email:
rafieian@yahoo.com
Abstract
Introduction: Dyslipidemia and high blood pressure in diabetic patients increase the risk of microvascular and macrovascular complications.Objectives: This study was conducted to investigate the association between serum lipids and level of blood pressure in type 2 diabetic patients (T2D).Patients and Methods: A prospective analytical study was carried out in 60 patients with T2D of both genders. None of the patients had a history of hypertension, and none was treated with antihypertensive drugs. Resting systolic blood pressures and fifth phase diastolic blood pressures were measured three times while the subjects were seated, and the results were averaged second and third measurements. Sixty patients with T2D were enrolled to the study. None of the patients who had a history of gout, was treated with allopurinol or treated with antihypertensive drugs previously.Results: Of 60 participants, mean of serum creatinine was 0.98±0.22 mg/dL. Mean of systolic and diastolic blood pressure was 133±13 mmHg and 84±7.4 mmHg respectively. In this study, a significant positive correlation of serum cholesterol with systolic (r=0.598, p=0.001) and diastolic blood pressure (r=0.584, p=0.001) was seen. Also the associations of serum LDL-C with systolic and diastolic blood pressure were as follow (r = 0.335, p<0.001) and (0.491, p<0.001) respectively. Associations of HDL-C with systolic and diastolic blood pressure were not significance as follow -0.05 and 0.04 respectively.Conclusion: The results of this study suggest that serum cholesterol has a strong association with levels of systolic and diastolic blood pressure in T2D patients. More attention to serum lipids and treatment of dyslipidemia could halt the progress of diabetic kidney disease.