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Original Article
A biochemical study on ameliorative effect of green tea (Camellia sinensis) extract against contrast media induced acute kidney injury
Hamid Nasri
1, Ali Ahmadi
2, Azar Baradaran
3, Parto Nasri
4, Shabnam Hajian
4, Armita Pour-Arian
4, Golnoosh Kohi
5, Mahmoud Rafieian-Kopaei
5*1 Department of Nephrology, Division of Nephropathology, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Epidemiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran
4 Nickan Research Institute, Isfahan, Iran
5 Medical Plants Research Center, Shahrekord University of Medical Sciences, Sharekord, Iran
*Corresponding Author: *Corresponding author: Prof. Mahmoud Rafieian-kopaei, Medical Plants Research Center, Shahrekord University of Medical Sciences, Sharekord, Iran., Email:
rafieian@yahoo.com
Abstract
Introduction: Reactive oxygen species have been shown to be mediators of kidney injury and green tea polyphenols are potent-free radical scavengers.Objectives: In this study we sought to examine whether green tea was able to protect renal toxicity induced by contrast media or not.Materials and Methods: In this experimental study 40 rats were randomly divided into four groups including: 1) control group 2) contrast media group 3) contrast media plus green tea 4) Green tea pretreatment and contrast media group. Blood urea Nitrogen (BUN) and serum creatinine were assessed for severity of kidney injury.Results: Serum creatinine level was higher in group II than in other groups (p<0.001). Treatment (group 3) or pretreatment (group 4) with green tea significantly reduced blood creatinine level when compared with contrast media group (group 2).Conclusion: In this study, beneficial property of green tea, against renal toxicity of contrast media was observed. Green tea extract is an inexpensive, nontoxic, and effective treatment modality in individuals with a risk for acute kidney injury of contrast media.
Implication for health policy/practice/research/medical education:
In an experimental study on 40 rats beneficial property of green tea (Camellia sinensis) extract, against renal toxicity of contrast media was observed. Green tea extract is an inexpensive, nontoxic, and effective treatment modality in individuals with a risk for acute kidney injury of contrast media.
Please cite this paper as: Nasri H, Ahmadi A, Baradaran A, Nasri P, Hajian S, Pour-Arian A, et al. A biochemical study on ameliorative effect of green tea (Camellia sinensis) extract against contrast media induced acute kidney injury. J Renal Inj Prev 2014; 3(2):47-49. DOI: 10.12861/jrip.2014.16