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ePublished: 01 Sep 2015
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J Renal Inj Prev. 2015;4(3): 87-91.
doi: 10.12861/jrip.2015.17
PMID: 26468480
PMCID: PMC4594219
  Abstract View: 2718
  PDF Download: 1347

Original Article

Comparison between the effects of one-day treatment regimen with cisplatin on renal function and various biochemical parameters in patients with gastric and lung cancer compared with two-days divided cisplatin treatment regimen

Ahmad Ahmadzadeh 1, Heshmatollah Shahbazian 2, Neda Safapour 1*, Mehri Tulabi 1, Sepideh Zandifar 3

1 Department of Hematology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Chronic Kidney Disease Research Center, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3 Department of Neurology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
*Corresponding Author: *Corresponding author: Neda Safapour, , Email: neda62safapour@yahoo.com

Abstract

Introduction: Cisplatin is an efficient chemotherapeutic drug used for the treatment of different cancers. Clinical trials represents cisplatin-induced nephrotoxicity in a dose dependent manner.

Objectives: This study aimed to compare the effects of 1-day treatment regimen with cisplatin on renal function, potassium, calcium, magnesium and uric acid in patients with gastric and lung cancer compared with 2-day divided cisplatin treatment regimen to suggest appropriate management for decrease nephrotoxic effects and electrolyte abnormalities.

Patients and Methods: The study was conducted as a randomized clinical trial. The sample consisted of 60 patients with gastric and lung cancer treated with cisplatin in Ahvaz Shafa hospital. Patients were randomly divided into 2 equal groups. Both groups were treated with cisplatin over a period of 6 to 18 weeks. The first group received 50 mg/m2/day of cisplatin during one day and the second group received 25 mg/m2/day in 2 days. Electrolytes in each period and renal function at baseline and 6 months after starting treatment was assessed.

Results: Difference of mean of renal function and nephrotoxicity incidence in the 2 groups was statistically significant. The odds of hypokalemia in 1-day group was higher than 2-day group (odds ratio [OR] = 6.5), which was statistically significant. However there was no significant relationship between the types of treatment and the risk of hypocalcemia, hypomagnesemia and hyperuricemia. Conclusion: The result of this study showed that, the divided administration of cisplatin reduces the nephrotoxic and hypokalemia effects of this drug, however it had not significant influence on hypomagnesemia, hypocalcaemia, and hyperuricemia.


Implication for health policy/practice/research/medical education:

Two of the most serious toxic effects of cisplatin are nephrotoxicity and electrolyte abnormalities. Therefore, assessment of renal function in patients treated with cisplatin in the early stages of treatment is necessary to prevent permanent damage to the kidneys. In a study, we found that, the divided administration of cisplatin reduces the nephrotoxic and hypokalemia effects of this drug, however it had not significant effect on hypocalcaemia, hypomagnesemia and hyperuricemia.

Please cite this paper as: Ahmadzadeh A, Shahbazian H, Safapour N, Tulabi M, Zandifar S. Comparison between the effects of one-day treatment regimen with cisplatin on renal function and various biochemical parameters in patients with gastric and lung cancer compared with two-days divided cisplatin treatment regimen. J Renal Inj Prev. 2015; 4(3): 87-91. DOI: 10.12861/jrip.2015.17

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