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ePublished: 01 Sep 2015
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J Renal Inj Prev. 2015;4(4): 109-112.
doi: 10.12861/jrip.2015.23
PMID: 26693496
PMCID: PMC4685979
  Abstract View: 3866
  PDF Download: 1546

Original Article

Evaluation of the protective effect of N-acetylcysteine on contrast media nephropathy

Aiyoub Pezeshgi 1,2, Negin Parsamanesh 2, Goodarz Farhood 2, Khalil Mahmoodi 2*

1 Zanjan Metabolic Disease Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
2 Department of Internal Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
*Corresponding Author: *Corresponding author: Khalil Mahmoodi, , Email: khalil_mahmoodi@zums.ac.ir

Abstract

Introduction: Intravenous contrast agents can cause acute decline in kidney function, especially in patients with risk factors. Objectives: In this study, we aimed to examine the ameliorative effect N-acetylcysteine (NAC) to reduce the incidence of contrast nephropathy.

Patients and Methods: This study was a prospective, randomized, double-blind clinical trial on 150 patients who underwent coronary angiography. The study was carried out on patients undergoing coronary angiography. Patients were randomly assigned into 2 groups of intervention group and control subjects. Intervention group took NAC 600 mg orally twice a day. It was administered one day before angiography and continued until the second day after angiography. Control subjects received saline only. Serum creatinine was measured before and three days after coronary angiography.

Results: There was no significant difference between intervention and control groups at baseline (P > 0.05). However, there was a significant decline in creatinine level among NAC patients (P = 0.001). Saline group had significantly higher proportion of nephropathy cases than NAC patients

Conclusion: We found that the consumption of NAC is useful for contrast induced nephropathy (CIN) prevention.


Implication for health policy/practice/research/medical education:

In a prospective, randomized, double-blind clinical trial on 150 patients who underwent coronary angiography, we found that the use of N-acetylcysteine (NAC) is useful for contrast induced nephropathy (CIN) prevention.

Please cite this paper as: Pezeshgi A, Parsamanesh N, Farhood G, Mahmoodi K. Evaluation of the protective effect of N-acetylcysteine on contrast media nephropathy. J Renal Inj Prev. 2015;4(4):109-112. DOI: 10.12861/jrip.2015.23

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