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J Renal Inj Prev. 2016;5(1): 25-28.
doi: 10.15171/jrip.2016.06
PMID: 27069964
PMCID: PMC4827382
  Abstract View: 4608
  PDF Download: 2060

Original Article

Correlation of cystatin C and creatinine based estimates of renal function in children with hydronephrosis

Hossein-Emad Momtaz 1*, Arash Dehghan 2, Mohammad Karimian 2

1 Division of pediatric nephrology, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
2 Department of Pathology, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
*Corresponding Author: *Corresponding author: Hossein-Emad Momtaz, , Email: hemmtz@yahoo.com

Abstract

Introduction: The use of a simple and accurate glomerular filtration rate (GFR) estimating method aiming minute assessment of renal function can be of great clinical importance.

Objectives: This study aimed to determine the association of a GFR estimating by equation that includes only cystatin C (Gentian equation) to equation that include only creatinine (Schwartz equation) among children.

Patients and Methods: A total of 31 children aged from 1 day to 5 years with the final diagnosis of unilateral or bilateral hydronephrosis referred to Besat hospital in Hamadan, between March 2010 and February 2011 were consecutively enrolled. Schwartz and Gentian equations were employed to determine GFR based on plasma creatinine and cystatin C levels, respectively.

Results: The proportion of GFR based on Schwartz equation was 70.19± 24.86 ml/min/1.73 m2, while the level of this parameter based on Gentian method and using cystatin C was 86.97 ± 21.57 ml/min/1.73 m2. The Pearson correlation coefficient analysis showed a strong direct association between the two levels of GFR measured by Schwartz equation based on serum creatinine level and Gentian method and using cystatin C (r = 0.594, P < 0.001). The linear association between GFR values measured with the two methods included cystatin C based GFR = 50.8+ 0.515 × Schwartz GFR. The correlation between GFR values measured by using serum creatinine and serum cystatin C measurements remained meaningful even after adjustment for patients’ gender and age (r = 0.724, P < 0.001).

Conclusion: The equation developed based on cystatin C level is comparable with another equation, based on serum creatinine (Schwartz formula) to estimate GFR in children.


Implication for health policy/practice/research/medical education:

In this study we aimed to evaluate the benefit of using serum cystatin C based glomerular filtration rate (GFR) calculation instead of creatinine based formula to early prediction of which hydronephrotic children need surgical intervention. Results of our study showed that in hydronephrotic children, cystatin C based calculation of GFR, is closely related to creatinine based formula but cannot predict early decline of GFR in these patients.

Please cite this paper as: Momtaz HE, Dehghan A, Karimian M. Correlation of cystatin-C and creatinine based estimates of renal function in children with hydronephrosis. J Renal Inj Prev. 2016;5(1):25-28. DOI: 10.15171/jrip.2016.06

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