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ePublished: 09 May 2016
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J Renal Inj Prev. 2016;5(3): 118-122.
doi: 10.15171/jrip.2016.25
PMID: 27689106
PMCID: PMC5039996
  Abstract View: 3205
  PDF Download: 1770

Original Article

The evaluation of relationship between blood pressure and dialysate Na concentration in chronic hemodialysis patients
 

Narges Sadat Zahed, Omid Gharooi*, Latif Gachkar, Hajar Nikbakht

1 Department of Nephrology, Loghman Hakim Clinical Research Development Center, Shahid Beheshti University of Medical sciences (SBUM), Tehran, Iran
*Corresponding Author: *Corresponding author: Omid Gharooi, , Email: lcrdc.sbum@gmail.com

Abstract

Introduction: Hypertension is one of the traditional risk factors of cardiovascular disease (CVD). Extra cellular volume expansion and Na retention remain the main cause of hypertension.

Objectives: The aim of this study was to investigate the relation between concentration of Na dialysate and blood pressure (BP) in chronic hemodialysis (HD) patient.

Patients and Methods: This cross-sectional study was performed on 266 adult patients undergoing HD for at least three months. Pre-HD systolic BP (SBP) and post-HD SBP during 4 weeks were measured in relation to Na dialysate concentration. The other main factors affecting the post-dialysis BP, such as body mass index (BMI), pump speed, dialysis solution temperature, duration of dialysis and intradialysis weight gain (IDWG) were also considered. Mean of ΔSBP (post-HD SBP – pre-HD SBP) in each patient in 12 session of HD was measured and statistically analyzed in relation to dialysate Na with SPSS 21. Backward multivariable linear regression analysis and Pearson’s correlation coefficients were used to evaluate the correlation between sodium gradient and ΔSBP.

Results: SBP was significantly changed before and after dialysis in relation to dialysate Na (P<0.001). The Pearson’s correlation between ΔSBP with dialysate sodium and blood flow rate (pump speed) were statistically significant(P<0.05).

Conclusion: We found that changes in SBP before and after dialysis is significantly associated with dialysate sodium concentration.

 


Implication for health policy/practice/research/medical education:

About 50% to 90% of dialysis population have hypertension. A relation between chronic volume expansion and mortality is well established. Dialysate sodium concentration is proposed as one of several factors which can control the blood pressure (BP) in dialysis patients. The aim of this study was to investigate the relation between concentration of Na dialysate and BP in chronic hemodialysis (HD) patients. This cross-sectional study was performed on 266 adult patients undergoing HD for at least three months. We found that changes in systolic BP before and after dialysis is significantly associated with dialysate sodium concentration.

Please cite this paper as: Zahed NS, Gharooi O, Gachkar L, Nikbakht H.The evaluation of relationship between blood pressure and dialysate Na concentration in chronic hemodialysis patients. J Renal Inj Prev. 2016;5(3):118-122. DOI: 10.15171/jrip.2016.25

 
 
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