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ePublished: 27 Jul 2016
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J Renal Inj Prev. 2016;5(4): 174-178.
doi: 10.15171/jrip.2016.37
PMID: 27689118
PMCID: PMC5039984
  Abstract View: 3680
  PDF Download: 1562

Original Article

Association of bone mineral density with biochemical markers of bone turnover in hemodialysis children
 

Niloofar Hajizadeh 1, Mehryar Mehrkash 2*, Daryoosh Fahimi 3, Mostafa Qorbani 4, Nina Shafa 5

1 Department of Pediatric Nephrology, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Pediatric Nephrology, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of Pediatric Nephrology, Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran
4 Department of Community Medicine, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
5 Iranian Resaerch Center on Ageing, University of Social Walfare and RehabilitationSciences,Tehran, Iran
*Corresponding Author: *Corresponding author: Mehryar Mehrkash, , Email: dr.mehrkash@yahoo.com

Abstract

Introduction: Although some descriptive and cross-sectional studies have been reported about bone mass in chronic kidney disease (CKD) children, only a few studies investigated markers of bone turnover and the bone mass measurements.

Objectives: The aim of this study was to evaluate the association between bone mineral density (BMD) and biochemical markers of bone turnover in hemodialysis (HD) children.

Patients and Methods: The children who had received dialysis for at least the preceding 6‐month were included. BMD was measured for total body, the lumbar spine and the femoral neck and the blood samples were tested to assess biochemical bone turnover markers.

Results: The study group was comprised of 27 patients with CKD, 9 males (33%) and 18 females (67%) with the mean±SD age of the subjects 14.9±4.5 years. Positive significant correlations of parathyroid hormone (PTH) with total body bone densitometry Z-score, lumbar spine and femoral neck Z-score(r=0.43, P=0.06; r=0.41, P=0.08 and r=0.45, P=0.05, respectively) was noted. In addition, positive significant correlations calcium and total body, lumbar spine and femoral neck Z-score (r=0.52, P=0.02; r=0.28, P=0.23 and r=0.36, P=0.12, respectively) was seen. Interestingly, a positive significant correlation between alkaline phosphatase (ALP) and lumbar spine Z-score was found (r=0.46, P=0.04), while the correlation of this parameter with total body and femoral neck Z-score was not significant (P>0.05).

Conclusion: In our study, majority of patients with CKD had low level of BMD. In addition, lower levels of calcium (Ca), phosphorus (P), PTH and 25 (OH) vitamins D in patients with abnormal BMD Z-scores were detected.

 

Implication for health policy/practice/research/medical education:

In a study on 27 patients with chronic kidney disease (CKD), with the age of 14.9 ± 4.5 years, we found, positive correlations of parathyroid hormone (PTH) with total body, lumbar spine and femoral neck Z-score. In addition, a positive correlation between calcium and total body, lumbar spine and femoral neck Z-score was found. Interestingly, positive correlations between alkaline phosphatase (ALP) and lumbar spine Z-score was found too, while the correlation of this parameter with total body and femoral neck Z-score was not significant. In our study a majority of patients with CKD had low level of bone mineral density (BMD). In addition, lower levels of calcium (Ca), phosphorus (P) PTH, 25 (OH) vitamins D were found in patient with abnormal BMD Z-scores.

Please cite this paper as: Hajizadeh N, Mehrkash M, Fahimi D, Qorbani Q, Shafa N. Association of bone mineral density with biochemical markers of bone turnover in hemodialysis children. J Renal Inj Prev. 2016;5(4):174-178. DOI: 10.15171/jrip.2016.37

 
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