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ePublished: 30 May 2016
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J Renal Inj Prev. 2016;5(4): 179-182.
doi: 10.15171/jrip.2016.38
PMID: 27689119
PMCID: PMC5039985
  Abstract View: 3841
  PDF Download: 1819

Original Article

Effect of selenium supplementation on lipid profile in hemodialysis patients
 

Hamidreza Omrani 1, Sima Golmohamadi 1*, Yahya Pasdar 2, Kambiz Jasemi 3, Afshin Almasi 4

1 Nephrology and Urology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
2 Department of Nutrition, Kermanshah University of Medical Sciences, Kermanshah, Iran
3 Department of Internal Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
4 Department of Biostatistics and Epidemiology, Kermanshah University of Medical Sciences, Kermanshah, Iran
*Corresponding Author: *Corresponding author: Sima Golmohamadi, , Email: simag_2000@yahoo.com

Abstract

Introduction: One of the major causes of mortality in chronic kidney disease (CKD) patients on hemodialysis is premature atherosclerosis. Selenium, a trace element involved in important enzymatic activities inside the body, has protective effects against lipid oxidation and inhibits cholesterol accumulation in blood vessels.

Objectives: To determine the effect of selenium supplementation on lipid profile in hemodialysis patients.

Patients and Methods: In this double-blinded randomized clinical trial which lasted for 3 months, 84 hemodialysis patients with selenium deficiency were divided into experimental group (received selenium supplementation) or control group (received placebo). Total cholesterol, low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), blood urea nitrogen (BUN), creatinine, and selenium level were measured before and after the study.

Results: Mean (±SD) serum LDL-C level significantly increased in experimental group from 85.66 (±31.12) to 109.12 (±32.29) mg/dl (P<0.001). Likewise, in control group serum LDL-C significantly increased from 80.55 (±21.13) to 97.05 (±28.07) mg/dl (P<0.001). However, with control of LDL-C effect before and after the study, it was revealed that LDL-C change was not statistically significant (P=0.21). Similarly, total cholesterol and triglyceride levels did not show significant changes before and after the study in any group.

Conclusion: Selenium supplementation had no beneficial effect on lipid profile in hemodialysis patients.

 

Implication for health policy/practice/research/medical education:

Since there is controversy about selenium supplementation on lipid profile in patients with hemodialysis patients, we conducted a study to determine the role of omega-3 in such patients. Our results showed that in short-term follow-up selenium supplementation, selenium supplementation had no beneficial effect on lipid profile in hemodialysis patients.


Please cite this paper as:
Omrani H, Golmohamadi S, Pasdar Y, Jasemi K, Almasi A. Effect of selenium supplementation on lipid profile in hemodialysis patients. J Renal Inj Prev. 2016;5(4):179-182. DOI: 10.15171/jrip.2016.38

 
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