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J Renal Inj Prev. 2017;6(3): 164-170.
doi: 10.15171/jrip.2017.32

Scopus ID: 85019712907
  Abstract View: 6334
  PDF Download: 3593

Review Article

Phytotherapy and phytopharmacology for reduction of cyclophosphamide-induced toxicity in the male urinary system

Mohammad Afkhami-Ardakani 1, Shapour Hassanzadeh 1, Rasoul Shahrooz 1, Majid Asadi-Samani 2*, Ebrahim Latifi 3, Tahra Luther 4

1 Department of Basic Sciences, Faculty of Veterinary, Urmia University, Urmia, Iran
2 Student Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran
3 Ferdowsi University of Mashhad, Mashhad, Iran
4 Department of General Surgery, University of Michigan, Ann Arbor, MI, USA
*Corresponding Author: *Corresponding author: Majid Asadi-Samani,, Email: biology_2011@yahoo.com


This systematic review was conducted to evaluate the protective effects and the role of medicinal plants and their derivatives in reducing the cyclophosphamide-induced side effects in the male urinary system. For this systematic review, the search terms cyclophosphamide, urinary system, male reproductive system, toxicity, cancer, chemotherapy, and side effects in combination with the terms medicinal plants, herbal medicines, and natural compounds were used to search for the relevant publications indexed in Google Scholar, Information Sciences Institute, Scopus, and PubMed. Fifteen plant extracts, two essential oils, three plant active components, and two herbal medicines were introduced. According to the results, plants with antioxidant compounds, such as flavonoids, are able to reduce cyclophosphamide-induced testicular toxicity. It is therefore recommended that the plants with significant antioxidant effects be prescribed alongside cyclophosphamide and their effects be compared with other plants plants and their derivatives.

Implication for health policy/practice/research/medical education:

The introduced medicinal plants in this systematic review can reduce cyclophosphamide induced toxicity in testicular tissue and therefore exert their protective effects on the drugs’ side effects. They can be used for discovering new drugs by evaluating their effects in clinical trials.

Please cite this paper as: Afkhami-Ardakani M, Hassanzadeh S, Shahrooz R, Asadi-Samani M, Latifi M, Luther T. Phytotherapy and phytopharmacology for reduction of cyclophosphamide-induced toxicity in the male urinary system. J Renal Inj Prev. 2017;6(3):164-170. DOI: 10.15171/jrip.2017.32.

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