Submitted: 10 Mar 2020
Accepted: 20 Mar 2020
ePublished: 22 Mar 2020
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J Renal Inj Prev. 2020;9(2): e18.
doi: 10.34172/jrip.2020.18

Scopus ID: 85085259652
  Abstract View: 3290
  PDF Download: 2002

Epidemiology and Prevention

Coronavirus-nephropathy; renal involvement in COVID-19

Rohollah Valizadeh 1* ORCID logo, Azar Baradaran 2 ORCID logo, Azin Mirzazadeh 3,4 ORCID logo, Lakkakula VKS Bhaskar 5

1 Department of Epidemiology, Student Research Committee, School of Public Health, Iran University of Medical science, Tehran, Iran
2 Nickan Research Institute, Isfahan, Iran
3 Joint Bioinformatics Graduate Program, University of Arkansas Little Rock and University of Arkansas for Medical Sciences, Little Rock, AR, USA
4 Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
5 Guru Ghasidas Vishwavidyalaya, Bilaspur, India
*Corresponding Author: *Corresponding author: Rohollah Valizadeh, Email: valizadeh.r@tak.iums.ac.ir, , Email: rohvali4@gmail.com

Implication for health policy/practice/research/medical education:

Renal disturbances by coronavirus disease 2019 (COVID-19), consisted of acute kidney injury, due to acute tubular necrosis induced by sepsis, hydration, cytokine storm syndrome, rhabdomyolysis and hypoxia. As the direct cytopathic effect of virus on various renal cells has been detected in previous studies, direct virus invasion to the renal tubular cells and interstitium or glomeruli is possible. Previous studies showed that coronavirus enters into the cells by angiotensin-converting enzyme II receptors that are extensively presented in the renal cells. Further, acute kidney injury in COVID-19 is strongly associated with higher mortality and morbidity and is an indicator for survival with Coronavirus infection. In the overall approach to patients with COVID-19 infection, special attention should be paid to control of classical risk factors of kidney injury.

Please cite this paper as: Valizadeh R, Baradaran A, Mirzazadeh A, Bhaskar LVKS. Coronavirus-nephropathy; renal involvement in COVID-19. J Renal Inj Prev. 2020; 9(2): e18. doi: 10.34172/jrip.2020.18.

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