Abstract
Introduction: The impact of cardiovascular disorders on morbidity and mortality of hemodialysis (HD) patients is considerable. Several markers have been investigated for renal disease and kidney transplantation.
Objectives: The aim of this study was to assess the correlation between three inflammatory biomarkers including pentraxin-3 (PTX-3), highly sensitive C-reactive protein (hs-CRP), and mannose-binding lectin (MBL) with cardiovascular disease (CVD) events and mortality in HD patients.
Patients and Methods: This longitudinal study was conducted on 18-80 years-old chronic kidney disease patients undergoing HD. The participants were followed every six months for 12 months and the occurrence of CVD events was determined with the calculation of left ventricular ejection fraction (LVEF) through echocardiography.
Results: Among 90 patients with a mean age of 54.0±3.24 years, MBL and PTX-3 showed a significant correlation to detect CVD events (r=0.987; P<0.001). The mean PTX-3, MBL and hs-CRP levels were not significantly different among the three ejection fraction groups (P>0.05), since none of these markers reached statistical significance for the prediction of mortality (P>0.05). A significant correlation was found between PTX-3, MBL and hs-CRP, while all of these markers increased in patients with cardiovascular complications (P<0.05).
Conclusion: In our study, PTX-3, MBL and hs-CRP significantly increased in HD patients who had LVEF with decreasing value. The serum concentration of PTX-3 MBL and hs-CRP can be considered a diagnostic tool for early detection of CVD events in end-stage renal disease (ESRD) patients.